以下是详细的报错，大大们看看是什么样的问题呢，谢谢啦
Request
Url: https://tlhak-webmail.langhamhotels.com:443/owa/auth/error.aspx?url=https://tlhak-webmail.langhamhotels.com/owa/&reason=0
OWA version: 14.3.279.2

Exception
Exception type: Microsoft.Exchange.Clients.Owa.Core.OwaInvalidConfigurationException
Exception message: Web object 'IIS://TLHAK-EXG-01.tlhak.langhamhotels.com/W3SVC/1/ROOT' can't be found.

Call stack

Microsoft.Exchange.Clients.Owa.Core.OwaConfigurationManager.CreateAndLoadConfigurationManager()

Microsoft.Exchange.Clients.Owa.Core.OwaSettingsLoaderBase.Load()

Microsoft.Exchange.Clients.Owa.Core.OwaSettingsLoader.Load()
Microsoft.Exchange.Clients.Owa.Core.OwaApplicationBase.ExecuteApplicationStart(Object sender, EventArgs e)
Inner Exception
Exception type: Microsoft.Exchange.Management.Metabase.WebObjectNotFoundException
Exception message: Web object 'IIS://TLHAK-EXG-01.tlhak.langhamhotels.com/W3SVC/1/ROOT' can't be found.

Call stack

Microsoft.Exchange.Management.Metabase.IisUtility.GetWebSiteName(String webSiteRootPath)

Microsoft.Exchange.Clients.Owa.Core.OwaConfigurationManager.InitializeConfigurationManager()
Microsoft.Exchange.Clients.Owa.Core.OwaConfigurationManager.CreateAndLoadConfigurationManager()
Inner Exception
Exception type: System.Runtime.InteropServices.COMException
Exception message: Access is denied.

Call stack

System.DirectoryServices.DirectoryEntry.Bind(Boolean throwIfFail)

System.DirectoryServices.DirectoryEntry.Bind()

System.DirectoryServices.DirectoryEntry.get_Parent()
Microsoft.Exchange.Management.Metabase.IisUtility.GetWebSiteName(String webSiteRootPath)